Refractory Cancerrefractory Disease
Differentiated thyroid cancer refractory to standard
The availability of kinase inhibitors that can stabilize progressive metastatic disease has changed the standard approach to treating patients whose disease no longer responds to radioiodine and TSH suppressive hormone therapy Although it may take many months before radiographic response becomes evident targeting angiogenesis and specifically vascular endothelial growth factor receptor
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Aureus Oropharyngeal ColonizationSecondaryStage II Non Small Cell Lung Cancer AJCC v7Inhalation of OzoneAphakiaInfrainguinal Peripheral Arterial DiseaseInflammation VaginaSolar Skin
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Pharmaceutics XXXX XXX 000000 CONCLUSIONS Placing nanomedicine s under the microscope reveals a rich complex dynamic and lively environment that is rapidly evolving moment by moment Harnessing the undoubted potential will make a
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In this article we show that a G47Δ shows enhanced antitumor activity in prostate cancer cells in vitro and in vivo b combination therapy of G47Δ and androgen ablation has cooperative effects resulting in greater inhibition of tumor growth than either therapy alone and c G47Δ is also effective for those prostate cancers that once responded to androgen ablation but eventually became refractory and
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Objective The aim of this retrospective study was to assess HAIC of 5 fluorouracil 5FU in patients with unresectable liver metastases from CRC refractory to standard systemic chemotherapy Methods A total of 137 patients 85 men 52 women median age 62 years with KRAS mutation n = 57 were recruited from seven institutions from September 2008 to December 2015
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Continued technology canceracute lymphocytic leukemia ALL hepatitis C hepatitis C chemotherapy induced neutropenia severe combined immune deciency syndrome acromegalia treatment of anemia associated with chronic kidney disease i rheumatoid arthritis Crohns disease PolymerAptamer Conjugate AMD Polymeric Drugs multiple sclerosis end stage renal failure type 2 diabetes
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Early Phase 1 studies assessing the safety and efficacy of AG‐120 in 258 subjects with mIDH1 advanced hematologic malignancies including relapsed/refractory R/R AML indicated acceptable tolerability with the majority of adverse events being diarrhea leukocytosis nausea fatigue febrile neutropenia dyspnea anemia QT prolongation peripheral edema pyrexia and decreased appetite
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For the purpose of this article refractory advancedbreast cancer is partially and arbitrarily defined as primaryor acquired resistance to hormonal therapies anthracycline resistance and failure of some otherwise undefined number of prior cytotoxicchemotherapeutic regimens
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cancerrefractory to at least one line of endocrine therapy in the metastatic setting or diagnosed with metastatic breast cancer during or within 1 year of adjuvant endocrine therapy evalu able disease as defined by Response Evaluation Criteria In Solid Tumors RECIST age 18 years life expectancy 6
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