Refractory Vs Resistant Cancer
Platinum Resistant and Refractory Ovarian Cancer
Patients with recurrent ovarian cancer who have a complete response to initial chemotherapy and a treatment free interval <6 months demonstrate platinum resistance 5 6 Refractory ovarian cancer is defined as stable or progressive disease during primary platinum based therapy 5 6 The difference between drug sensitive and drug resistant disease was initially described in relation to
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Hormone Refractory Prostate Cancer or Castrate Resistant
The Hormone Refractory Prostate Cancer HRPCa Association was a volunteer organization of one hundred men with HRPCa their family members and their caregivers that existed from 1999 to 2016 Members were from all over the U S Canada and the
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Is there a difference between platinum resistant and
Platinum refractory cancer grew while on platinum therapy Platinum resistant recurrance within 6 months of platinum treatment However I think they are more often than not used to
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platinum refractory Cancer Survivors Network
In patients with relapsed ovarian cancer the overall response rates on treatment with topotecan range from 19 33 in platinum sensitive patients 14 18 in platinum resistant patients and 5 11 in platinum refractory patients The proportion of patients achieving stable disease ranges between 17 in refractory and 48 in sensitive patients
Get PricePlatinum resistance refractoryOvarian Cancer Community
Report As to the platinum resistant v refractory question I understand that if you achieve a complete response after a platinum based therapy but then recur within six months ou are considered platinum resistant If you progress or recur in a very short time while on platinum based therapy you are considered platinum refractory
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Metastatic Castration Resistant Prostate Cancer What s
The term castration resistant refers to a cancer that is no longer responding to this type of therapy According to the American Society of Clinical Oncology ASCO many men with prostate
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Surgical Castration in Hormone Refractory Metastatic
Background Most patients with metastatic prostate cancer are endocrinologically treated with LHRH agonist but finally castration refractory and hormone refractory cancers occur Serum testosterone levels get low to the castration level by LHRH agonists but may not get low enough against castration refractory prostate cancer Methods
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What is Refractory Cancer and How Is It Treated Dana Farber
The word refractory in general use means stubborn or intractable and in medicine it is specifically applied to disease that does not respond to treatment Refractory cancer refers to cancer that may be resistant at the beginning of treatment or becomes resistant during treatment
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What are the treatment recommendations for platinum
Cannistra SA Matulonis UA Penson RT Hambleton J Dupont J Mackey H Phase II study of bevacizumab in patients with platinum resistant ovarian cancer or peritoneal serous cancer
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Refractory Metastatic Colorectal Cancer Current
Introduction Colorectal cancer CRC is a major global health issue being the third most commonly diagnosed malignancy with an estimated global incidence of over 1 8 million in 2018 predicted to increase to 2 2 million in 2030 1 2 CRC is the second commonest cause of global cancer mortality with 0 5 million deaths in 2018 predicted to increase to 1 1 million by 2030 1 2 Twenty percent of
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Definitions of Resistant and Refractory Cytomegalovirus
In this article we aim to define refractory and/or resistant CMV infections after SOT or HCT to provide consistent criteria for future clinical trials and outcomes research Clinical suspicion of drug resistant CMV infections is usually based on suboptimal responses to antiviral agents leading to a treatment refractory condition
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Treatment of platinum refractory or resistant ovarian cancer
For instance whole genome sequencing of DNA from high grade ovarian serous tumours and germline DNA samples showed that CCNE1 amplification is common in primary resistant or refractory disease whereas acquired chemotherapy resistance is closely related to gene breakage inactivating tumour suppressor genes RB1 NF1 RAD51B and PTEN as well as independent reversions of germline BRCA1 or BRCA2 mutations loss of BRCA1 promoter methylation and
Get PriceTherapeutic Options in Docetaxel Refractory Metastatic
Almost all patients become refractory to ADT and the disease becomes metastatic castration resistant prostate cancer mCRPC for which docetaxel is the standard of care Until recently there were few FDA approved options for patients who progressed following docetaxel treatment except for mitoxantrone which improves quality of life through
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What are the treatment recommendations for platinum
Cannistra SA Matulonis UA Penson RT Hambleton J Dupont J Mackey H Phase II study of bevacizumab in patients with platinum resistant ovarian cancer or peritoneal serous cancer
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Management of Patients With Resistant or Refractory
23 O Hare T Walters DK Stoffregen EP et al In vitro activity of Bcr Abl inhibitors AMN107 and BMS against clinically relevant imatinib resistant Abl kinase domain mutants Cancer Res 65 2005 24 Deininger M Buchdunger E Druker BJ The development of imatinib as a therapeutic agent for chronic myeloid leukemia
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Emerging Phase 3 Data in Relapsed/Refractory Metastatic
With its broad mechanism of action regorafenib can potentially suppress resistant clones not susceptible to a single drug with a single target H O What data support the use of the newer agents RG The phase 3 RECOURSE Study of TAS 102 in Patients With Metastatic Colorectal Cancer Refractory to Standard Chemotherapies trial evaluated TAS 102
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Clinical Challenges Platinum Resistant Ovarian Cancer
Women with platinum resistant or refractory relapsed epithelial ovarian cancer continue to have a poor prognosis and effective treatment of platinum resistance or even of preventing or
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What is hormone refractory prostate cancer
In patients with serum testosterone castrate levels hormone refractory prostate cancer is defined as 2 3 consecutive rises in prostate specific antigen PSA levels obtained at intervals of
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NCI Dictionary of Cancer TermsNational Cancer Institute
NCI s Dictionary of Cancer Terms provides easy to understand definitions for words and phrases related to cancer and medicine
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Castration Refractory Prostate Cancer New Therapies New
Resistance to androgen deprivation is an ominous milestone in the natural history of metastatic prostate cancer this disease state now referred to as castration refractory prostate cancer CRPC is historically associated with a median survival of less than two years Until recently only docetaxel in combination with prednisone or estramustine demonstrated a benefit in overall survival vs
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First line Treatment for Metastatic Castrate resistant
Petrylak DP Tangen CM Hussain MH et al Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer N Engl J Med Oct 7 15 Kantoff PW Higano CS Shore ND et al Sipuleucel T immunotherapy for castration resistant prostate cancer N Engl J Med Jul 29 5
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Avelumab in platinum resistant/refractory ovarian cancer
Women with PRROC ≤3 prior lines for platinum sensitive disease and no prior therapy for platinum resistant disease were randomized 1 1 1 to Ave 10 mg/kg Q2W Ave PLD 40 mg/m 2 Q4W or PLD Pts were stratified by platinum status refractory vs resistant prior regimens 1 vs 2 or 3 and bulky disease tumor ≥5 vs < 5 cm
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What is Refractory Cancer News Medical
The meaning of refractory cancer is cancer that fails to respond to medical treatment This may present as resistance to treatment from the start or the acquisition of resistance by the cancer
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Castration Resistant Prostate Cancer Treatment Outlook
Castrate resistant prostate cancer is prostate cancer that stops responding to hormone therapy Hormone therapy also called androgen deprivation
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Management of Platinum ResistantRefractory Ovarian
Ovarian cancer accounts for 3 of cancer deaths among women and is the most lethal gynecological malignancy The five year survival for all stages collectively is 45 6 and relapsed ovarian cancer is incurable Platinum resistance is a major prognostic determinant but the molecular pathways involved in resistance mechanism are unknown
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Chemotherapy vs Hormonal Treatment in Platinum resistant
Chemotherapy vs Hormonal Treatment in Platinum resistant Ovarian Cancer Resistant or Refractory to Platinum and Taxane The safety and scientific validity of this study is the responsibility of the study sponsor and investigators Listing a study does not mean it has been evaluated by the U S Federal Government
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Relapsed vs Refractory Multiple MyelomaVerywell Health
Refractory Multiple Myeloma Refractory is another word for resistant Refractory myeloma is cancer that develops resistance to treatment or does not respond to it at all There are two types of refractory myeloma Relapsed and refractory myeloma Myeloma that initially responds to treatment but then stops responding to it after a time or
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Success and failure of additional immune modulators in
to refractory cases steroid refractory median 68 days vs resistant median 182 days p=0 02 1D The figure median time from initial treatment with steroids to treat ment with additional immune modulator in steroid refractory patients was 7 days range 2 to 23 days 10/12 patients treated in <14 days In patients with resistant
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The Recurrent and Refractory Cancer Treatment Program is dedicated to working with patients whose cancers have recurred or are not responding to treatments Our team specialists work with the Children s Oncology Group COG and other experts to offer patients
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When cancer comes back or doesn t go away after hormonal therapy it is called castrate resistant hormone refractory prostate cancer Your doctor will know that you have castrate resistant prostate cancer if a blood test shows that your prostate specific antigen PSA level
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The Difference Between Relapsed Lymphoma and Refractory
Relapsed Cancer Relapsed refers to a cancer that returns after a period of improvement This applies whether the cancer was treated or untreated Refractory Cancer Refractory refers to a cancer that proves resistant or does not respond to treatment It doesn t matter whether the cancer is resistant to treatment immediately or whether it develops a resistance during treatment it is still called refractory
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Platinum Resistant and Refractory Ovarian Cancer
Patients with recurrent ovarian cancer who have a complete response to initial chemotherapy and a treatment free interval <6 months demonstrate platinum resistance 5 6 Refractory ovarian cancer is defined as stable or progressive disease during primary platinum based therapy 5 6 The difference between drug sensitive and drug resistant disease was initially described in relation
Get PriceWhat Is Relapsed vs Refractory Myeloma The Myeloma
Refractory Myeloma Dr Damian Green MD of the Fred Hutchinson Cancer Center generally defines Refractory Myeloma as disease that is progressing despite active treatment The National Cancer Institute breaks it down even further to say that there are two main types of refractory
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